Acetylthiourea → N-(4-[3-(2-hydroxyethyl)phenyl]-1,3-thiazol-2-yl}acetamide
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][OH:13])[CH:6]=1)=O.[C:14]([NH:17][C:18]([NH2:20])=[S:19])(=[O:16])[CH3:15]>O1CCCC1>[OH:13][CH2:12][CH2:11][C:7]1[CH:6]=[C:5]([C:3]2[N:20]=[C:18]([NH:17][C:14](=[O:16])[CH3:15])[S:19][CH:2]=2)[CH:10]=[CH:9][CH:8]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
To a solution of 2-bromo-1-[3-(2-hydroxyethyl)phenyl]ethanone (crude, 658 mg) in tetrahydrofuran (15 ml) was added 1-acetyl-2-thiourea (320 mg) at 25° C. The mixture was stirred at 60° C. for 2 h. The residual colorless crystals were collected by filtration. The crystals were washed with isopropyl ether, dried under reduced pressure to give N-{4-[3-(2-hydroxyethyl)phenyl]-1,3-thiazol-2-yl}acetamide (514 mg) as a colorless crystal.