2-Nitro-5-(trifluoromethoxy)benzoic acid → 2-amino-5-(trifluoromethoxy)benzoic Acid

HRID 1246637

反応式

HRID 1246637 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:15])([F:16])[F:17])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

4

反応物 1

HCID 219046132-Nitro-5-(trifluoromethoxy)benzoic acid

生成物 1

HCID 110853492-amino-5-(trifluoromethoxy)benzoic Acid収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 2-nitro-5-trifluoromethoxybenzoic acid (56.8 g, 0.23 mol; see step (i) above) in EtOH (1000 mL) was added 10% Pd/C (5.7 g). The resulting solution was flushed with H2 for 5 h, filtered through Celite® and concentrated in vacuo to give the crude sub-title compound (49.7 g, 98%) as a solid that was used in the next step without further purification.

後処理

  1. customThe resulting solution was flushed with H2 for 5 h
  2. filtrationfiltered through Celite®
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-254db98776474b5f9dea6e7e332eef06
出典データセット
uspto-grants-2006_10
特許番号
US07129233B2

関連ノート

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