Methyl iodide → 1-benzyl-2-(methoxycarbonyl)-5-(methylthio)-3,4-dihydro-2H-pyrrolium iodide

HRID 1246700ノート

反応式

HRID 1246700 の反応式
[CH2:1]([N:8]1[C:12](=[S:13])[CH2:11][CH2:10][CH:9]1[C:14]([O:16][CH3:17])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:18][CH3:19]>>[I-:18].[CH2:1]([N+:8]1[CH:9]([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:11][C:12]=1[S:13][CH3:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 6328Methyl iodideHCID 14759675Methyl 1-benzyl-5-thioxo-2-pyrrolidinecarboxylate

生成物 1

HCID 865958731-benzyl-2-(methoxycarbonyl)-5-(methylthio)-3,4-dihydro-2H-pyrrolium iodide

実験手順

Methyl 1-benzyl-5-thioxo-2-pyrrolidinecarboxylate (16.5 g, 66.2 mmol) in iodomethane (70 mL) was stirred overnight at room temperature. The mixture was concentrated under reduced pressure to provide the title compound which was used in the next step without further purification. 1H NMR (CDCl3) δ 2.24 (m, 1H), 3.04 (s, 3H), 3.16 (m, 1H), 3.25 (m, 1H), 3.63 (s, 3H), 4.29 (dd, 1H), 4.72 (d, 1H), 4.89 (dd, 1H), 5.14 (d, 1H), 7.43 (m, 3H), 7.51 (m, 2H).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7f98bbabb7804e23af4bd5e0ec642d2e
出典データセット
uspto-grants-2006_10
特許番号
US07129235B2

反応ノート

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