Methyl 1-benzyl-5-(nitromethylene)-2-pyrrolidinecarboxylate → 8-Benzyl-3,8-diazabicyclo[3.2.1]octan-2-one

HRID 1246702ノート

反応式

HRID 1246702 の反応式
[CH2:1]([N:8]1[C:12](=[CH:13][N+:14]([O-])=O)[CH2:11][CH2:10][CH:9]1[C:17]([O:19]C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pt].CO>[CH2:1]([N:8]1[CH:12]2[CH2:11][CH2:10][CH:9]1[C:17](=[O:19])[NH:14][CH2:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 66846370Methyl 1-benzyl-5-(nitromethylene)-2-pyrrolidinecarboxylate

生成物 1

HCID 219047238-Benzyl-3,8-diazabicyclo[3.2.1]octan-2-one

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

Methyl 1-benzyl-5-(nitromethylene)-2-pyrrolidinecarboxylate (9.92 g, 35.9 mmol) and 5% platinum on activated carbon (11.25 g) were combined in methanol (100 mL) and shaken for 56 hours at ambient temperature under a hydrogen atmosphere (60 psi). The misture was filtered and the filtrate concentrated to provide the title compound. MS (DCI/NH3) m/z: 217 (M+H)+.

後処理

  1. filtrationThe misture was filtered
  2. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-b08555579183468dabae223e51a9e25f
出典データセット
uspto-grants-2006_10
特許番号
US07129235B2

反応ノート

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