Trifluoroacetic acid → HCID 21906487、化合物

HRID 1247032ノート

反応式

HRID 1247032 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:32])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([CH:19]2[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]2)=[O:18])=[N:6][CH:7]=1.[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36]>ClCCl.C1(OC)C=CC=CC=1>[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:32])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:18])=[N:6][CH:7]=1

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 21906386HCID 21906386、化合物

生成物 1

HCID 21906487HCID 21906487、化合物収率 94.9%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 7519Anisole溶媒

実験手順

To a stirred solution of N-(5-chloropyridin-2-yl)-2-[(1-Boc-piperidin-4-ylcarbonyl)amino]benzamide (2 g, 4.3 mmol) in dichloromethane (80 mL) and anisole (2.4 mL) was added trifluoroacetic acid (8.4 mL, 109 mmol). After stirring for 4 h, the solvent was removed in vacuo. The residue was suspended in ether, sonicated for 0.25 h, stirred vigorously for 15 h, and filtered to give 1.93 g (94%) of a white solid.

後処理

  1. customthe solvent was removed in vacuo
  2. customsonicated for 0.25 h
  3. stirringstirred vigorously for 15 h
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-c20c1e13231d4fdfa1bbde8462e13039
出典データセット
uspto-grants-2006_10
特許番号
US07129245B2

反応ノート

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