Water → N-(5-Chloropyridin-2-yl)-2-[(1-isopropylpiperidin-4-ylcarbonyl)amino]-5-phenylbenzamide Hydrochloride

To a stirring solution of N-(5-chloropyridin-2-yl)-5-iodo-2-[(1-isopropylpiperidin-4-ylcarbonyl)amino]benzamide (0.29 g, 0.54 mmol), tetrakis(triphenylphosphine)palladium(0) (35 mg, 0.03 mmol), and phenylboronic acid (81 mg, 0.66 mmol) in toluene (5 mL) was added water (0.55 mL) and a 2 M aqueous sodium carbonate solution (0.55 mL, 1.1 mmol). The mixture was heated to 85–95° C. for 1 h, cooled to room temperature, partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was treated with 0.002 N aqueous hydrochloric acid. To the aqueous phase was added dichloromethane followed by saturated aqueous sodium bicarbonate until pH 8–9. The phases were separated and the organic phase was concentrated. The crude product was purified by RPHPLC, eluting with a gradient from 25% through 65% acetonitrile in 0.05% aqueous hydrochloric acid, to give 0.16 g (57%) of a yellow solid.

1. temperatureThe mixture was heated to 85–95° C. for 1 h
2. custompartitioned between ethyl acetate and saturated aqueous sodium bicarbonate
3. additionThe organic phase was treated with 0.002 N aqueous hydrochloric acid
4. additionTo the aqueous phase was added dichloromethane
5. customThe phases were separated
6. concentrationthe organic phase was concentrated
7. customThe crude product was purified by RPHPLC
8. washeluting with a gradient from 25% through 65% acetonitrile in 0.05% aqueous hydrochloric acid

ORDレコード

ord-4eabb420e7914c64a80d6f6f304f0a53

出典データセット

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07129245B2