Iodoethane → HCID 69290924、化合物

HRID 1247340ノート

反応式

HRID 1247340 の反応式
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][C:10]([O:14][CH3:15])=[CH:9][C:8]=1[F:16])[OH:6])[CH3:2].[CH2:18](I)[CH3:19]>C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][C:10]([O:14][CH3:15])=[CH:9][C:8]=1[F:16])[O:6][CH2:18][CH3:19])[CH3:2]

参加物

4

反応物 2

HCID 6340Iodoethane2 回HCID 69290984HCID 69290984、化合物

生成物 1

HCID 69290924HCID 69290924、化合物収率 100.4%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a suspension of (RS)-(2,6-difluoro-4-methoxy-phenyl)-hydroxy-acetic acid ethyl ester (13.06 g) and Ag2O (24.58 g) in toluene (100 ml) was added ethyl iodide (24.81 g). The mixture was heated to reflux for 2.5 h. Ethyl iodide (24.81 g) and Ag2O (12.29 g) were added and the mixture was refluxed for a further 7 h. The solid was filtered off and the filtate was concentrated to give (RS)-(2,6-difluoro-4-methoxy-phenyl)-ethoxy-acetic acid ethyl ester (14.6 g). Light yellow oil. MS 274.1 ([M]+)

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 2.5 h
  3. temperaturethe mixture was refluxed for a further 7 h
  4. filtrationThe solid was filtered off
  5. concentrationthe filtate was concentrated

出典と根拠

ORDレコード
ord-62330126982a4072ab1b9d27ce5ec46d
出典データセット
uspto-grants-2006_10
特許番号
US07129238B2

反応ノート

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