Hydroxyamine hydrochloride → 4-(Hydroxyimino-methyl)-3-phenoxy-benzonitrile

HRID 1247345ノート

反応式

HRID 1247345 の反応式
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O.C([O-])(=O)C.[Na+].Cl.[NH2:24][OH:25]>C(O)C>[OH:25][N:24]=[CH:1][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 219054244-Cyano-2-phenoxybenzaldehyde

生成物 1

HCID 865930434-(Hydroxyimino-methyl)-3-phenoxy-benzonitrile収率 60.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 4-formyl-3-phenoxy-benzonitrile (2.21 g) in dry ethanol (45 ml) was added sodium acetate (0.894 g) and hydroxylamine hydrochloride (0.757 g). The mixture was stirred at rt for 4.5 h. The solvent was evaporated and the product was purified by flash chromatography (cyclohexane/EtOAc 8:2=>3:7) to give 4-(hydroxyimino-methyl)-3-phenoxy-benzonitrile (1.42 g). Light yellow solid. MS 238.1 ([M]+)

後処理

  1. customThe solvent was evaporated
  2. customthe product was purified by flash chromatography (cyclohexane/EtOAc 8:2=>3:7)

出典と根拠

ORDレコード
ord-b1c3410b43504bfd829b5abcd5e5e57f
出典データセット
uspto-grants-2006_10
特許番号
US07129238B2

反応ノート

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