Water → 1H-Isoindol-1-one, 4-bromo-2,3-dihydro-7-methoxy-
反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:12].[C:13]([O-])([O-])=O.[Cs+].[Cs+].CI.O>CN(C=O)C>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:13])=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:12]参加物
6
実験手順
A solution of Example 106D (103 mg, 0.45 mmol) in DMF (4 mL) was treated with Cs2CO3 (162 mg, 0.5 mmol) and methyl iodide (0.03 mL, 0.48 mmol), stirred at room temperature for 3 hours, then poured into water. The resulting precipitate was filtered to give 76 mg (70%) of the desired product. MS (ESI(+)) m/e 242,244 (M+H)+.
後処理
- filtrationThe resulting precipitate was filtered
出典と根拠
- ORDレコード
- ord-26983ef7633a4dfd8fe5b31dd29a466a
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07129260B2
反応ノート
読み込み中…