13-cis-Acitretin → Acitretin

HRID 1247660

反応式

HRID 1247660 の反応式
[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]\[C:16]([OH:18])=[O:17])=[C:6]([CH3:21])[C:5]([CH3:22])=[C:4]([O:23][CH3:24])[CH:3]=1>CC(C)=O>[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]/[C:16]([OH:18])=[O:17])=[C:6]([CH3:21])[C:5]([CH3:22])=[C:4]([O:23][CH3:24])[CH:3]=1

参加物

3

反応物 1

HCID 643784113-cis-Acitretin

生成物 1

HCID 5284513Acitretin収率 98.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Crude acetretin (10 g) was added to acetone (300 ml) and stirred at 25–30° C. for 1 hour under nitrogen atmosphere. The suspension was then filtered, washed with acetone (100 ml) and dried under vacuum at 25–30° C. to obtain pure acitretin (8 g, Assay 98.3% by HPLC).

後処理

  1. filtrationThe suspension was then filtered
  2. washwashed with acetone (100 ml)
  3. customdried under vacuum at 25–30° C.

出典と根拠

ORDレコード
ord-0a6a1dd62a144e049522c3ad6075d89a
出典データセット
uspto-grants-2006_10
特許番号
US07129365B2

関連ノート

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