Hydrochloric Acid → 1H-Pyrazole-1-ethanol, 5-amino-4-nitroso-

HRID 1247787

反応式

HRID 1247787 の反応式
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][CH:3]=1.Cl.[N:11](OCCC(C)C)=[O:12]>C(O)C>[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][C:3]=1[N:11]=[O:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 3202812-(5-amino-1H-pyrazol-1-yl)ethan-1-ol

生成物 1

HCID 101490141H-Pyrazole-1-ethanol, 5-amino-4-nitroso-収率 51.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 5-amino-1-(2-hydroxyethyl)pyrazole (6.35 g) in a mixed solvent of ethanol (25 ml) and concentrated hydrochloric acid (0.035 ml) was added dropwise isoamyl nitrite (7.03 g). The mixture was stirred at room temperature for 17 hours. The crystalline residue was collected by filtration and dried in vacuo to give 5-amino-1-(2-hydroxyethyl)-4-nitrosopyrazole (4.0 g) as a solid.

後処理

  1. filtrationThe crystalline residue was collected by filtration
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-caef93d0f1284e4084569b09d22d8d2d
出典データセット
uspto-grants-2006_10
特許番号
US07129232B2

関連ノート

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