Ethanol → 3-Ethoxy-1-(3-pyridinyl)-2-propen-1-one

HRID 1247954

反応式

HRID 1247954 の反応式
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)=[O:6].C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH2:25]([OH:27])[CH3:26]>>[CH2:25]([O:27][CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)=[O:6])[CH3:26]

参加物

4

反応物 3

HCID 702EthanolHCID 6101p-Toluenesulfonic acidHCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

生成物 1

HCID 540323263-Ethoxy-1-(3-pyridinyl)-2-propen-1-one

実験手順

A mixture of 0.10 mole of 3-dimethylamino-1-(3-pyridinyl)-2-propen-1-one and 0.20 mole of p-toluenesulfonic acid in 150 ml of anhydrous ethanol was refluxed for 10 hours. The solvent was removed and the residue partitioned between water and dichloromethane. The organic layer was dried over magnesium sulfate and the solvent removed, giving 3-ethoxy-1-(3-pyridinyl)-2-propen-1-one.

後処理

  1. temperaturewas refluxed for 10 hours
  2. customThe solvent was removed
  3. customthe residue partitioned between water and dichloromethane
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. customthe solvent removed

出典と根拠

ORDレコード
ord-64c5b816faa34d3e82a72f8bd2cc1385
出典データセット
uspto-grants-1985_06
特許番号
US04521422

関連ノート

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