Ethyl formate → Ethyl 2-formyl-3-(3-methoxyphenyl)propionate

HRID 1248302ノート

反応式

HRID 1248302 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1.[CH:16](OCC)=[O:17].[Na]>CCOCC>[CH:16]([CH:10]([CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:17]

参加物

5

反応物 3

HCID 8025Ethyl formateHCID 584318Ethyl 3-(3-methoxyphenyl)propanoateHCID 5360545Sodium

生成物 1

HCID 10823703Ethyl 2-formyl-3-(3-methoxyphenyl)propionate収率 40.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of ethyl 3-(3-methoxyphenyl)propionate (100 g) and ethyl formate (37 g) was added dropwise to a mixture of sodium wire (11 g) in stirred ether (500 ml) at 0°. The mixture was stirred at room temperature for 16 hours and evaporated to dryness. The residue was dissolved in water and extracted with ether, the extracted aqueous phase was adjusted to pH 4 with hydrochloric acid and was extracted with ether and the ether extract was evaporated to dryness to give ethyl 2-formyl-3-(3-methoxyphenyl)propionate (46.05 g).

後処理

  1. customevaporated to dryness
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with ether
  4. extractionwas extracted with ether
  5. extractionthe ether extract
  6. customwas evaporated to dryness

出典と根拠

ORDレコード
ord-ac07dd5b2e46411589bdf49cb3e9e5f7
出典データセット
uspto-grants-1985_06
特許番号
US04523015

反応ノート

読み込み中…