Propargyl bromide → 5-Methyl-2-propargyloxyphenylsulfonamide
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].C(=O)([O-])[O-].[K+].[K+].[CH2:19](Br)[C:20]#[CH:21]>C(#N)C>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([O:1][CH2:21][C:20]#[CH:19])=[C:3]([S:9]([NH2:12])(=[O:10])=[O:11])[CH:4]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
A mixture of 24.3 g of 2-hydroxy-5-methylphenylsulfonamide, 36.0 g of potassium carbonate, 16.7 g of propargyl bromide and 500 ml of acetonitrile is stirred at 50° C. for 4.5 hours. The reaction mixture is then filtered, and concentrated by evaporation. The yield after recrystallisation from ethyl acetate is 23.9 g of 5-methyl-2-propargyloxyphenylsulfonamide, m.p. 169°-170° C.
後処理
- filtrationThe reaction mixture is then filtered
- concentrationconcentrated by evaporation
- customThe yield
- customafter recrystallisation from ethyl acetate
出典と根拠
- ORDレコード
- ord-127d623726274a86a75da5c167078b81
- 出典データセット
- uspto-grants-1985_06
- 特許番号
- US04523944
反応ノート
読み込み中…