5-(3-Pyridylmethyl)-4-pyrimidone → 2-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone

HRID 1248412

反応式

HRID 1248412 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7][C:8]1[O:12][C:11]([CH2:13][N:14]([CH3:16])[CH3:15])=[CH:10][CH:9]=1.[N:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][C:24]2[C:25](=[O:30])[NH:26][CH:27]=[N:28][CH:29]=2)[CH:18]=1>>[CH3:15][N:14]([CH2:13][C:11]1[O:12][C:8]([CH2:7][O:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:27]2[NH:26][C:25](=[O:30])[C:24]([CH2:23][C:19]3[CH:18]=[N:17][CH:22]=[CH:21][CH:20]=3)=[CH:29][N:28]=2)=[CH:9][CH:10]=1)[CH3:16]

参加物

3

反応物 2

HCID 204481775-(3-Pyridylmethyl)-4-pyrimidoneHCID 212975835-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine

生成物 1

HCID 202778842-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone収率 52.2%

実験手順

A mixture of 5-[(4-aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine (1 g) and 2-methylthio)-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone (1 g) was heated at 140° for 7 h. Column chromatography (silica/methanol) of the residue yielded the title compound (0.95 g) as a yellow oil.

後処理

  1. temperaturewas heated at 140° for 7 h

出典と根拠

ORDレコード
ord-0641ff2f19e949608b077180c477192a
出典データセット
uspto-grants-1985_06
特許番号
US04524071

関連ノート

読み込み中…