Hydrazinecarboxaldehyde → 4-(3',5'-Difluorobenzyl)-1-formyl-3-thiosemicarbazide
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][N:6]=[C:7]=[S:8].[CH:13]([NH:15][NH2:16])=[O:14]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][NH:6][C:7](=[S:8])[NH:16][NH:15][CH:13]=[O:14]参加物
4
実験手順
3,5-Difluorobenzyl isothiocyanate (9.9 g, 25.5 mmole) and formyl hydrazine (1.7 g, 28.7 mole) were refluxed in ethanol (30 ml) for one hour. The reaction was evaporated to dryness, triturated with hexane:ethyl acetate (1:1), filtered, and recrystallized from ethanol-hexane to yield 3.5 g (35%) of crude 4-(3',5'-difluorobenzyl)-1-formyl-3-thiosemicarbazide.
後処理
- customThe reaction was evaporated to dryness
- customtriturated with hexane:ethyl acetate (1:1)
- filtrationfiltered
- customrecrystallized from ethanol-hexane
出典と根拠
- ORDレコード
- ord-4dc888b8db6742b1b616bfaa639e4d60
- 出典データセット
- uspto-grants-1986_12
- 特許番号
- US04628059
反応ノート
読み込み中…