Hydrazine hydrate (1:1) → (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carbohydrazide

HRID 1249101ノート

反応式

HRID 1249101 の反応式
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][C@@H:3]([C:14]([O:16]CC)=O)[NH:2]1.O.[NH2:20][NH2:21]>CN(C)C=O>[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][C@@H:3]([C:14]([NH:20][NH2:21])=[O:16])[NH:2]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 1079579ethyl (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate

生成物 1

HCID 7109654(3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carbohydrazide収率 74%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of ethyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (4.9 g), hydrazine hydrate (10 ml) and dimethylformamide (50 ml) is allowed to stand at room temperature overnight. The reaction mixture is is distilled under reduced pressure to remove the solvent. The residue is treated with ethyl acetate to give the title compound (3.40 g, 74%) as powder.

後処理

  1. distillationThe reaction mixture is is distilled under reduced pressure
  2. customto remove the solvent
  3. additionThe residue is treated with ethyl acetate

出典と根拠

ORDレコード
ord-7bb566fabe9947ca831ad8d0c22c6d56
出典データセット
uspto-grants-1986_12
特許番号
US04628057

反応ノート

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