Sodium Hydroxide → HCID 762190、化合物

HRID 1249105ノート

反応式

HRID 1249105 の反応式
[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@@H:6]([C:17]([O:19]C)=[O:18])[NH:5]1)[CH2:2][CH3:3].[OH-].[Na+]>CO>[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@@H:6]([C:17]([OH:19])=[O:18])[NH:5]1)[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86741022HCID 86741022、化合物

生成物 1

HCID 762190HCID 762190、化合物収率 81.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of methyl (1RS,3RS)-cis-1-n-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (1.3 g), 1N NaOH (5.5 ml) and methanol (8 ml) is stirred at room temperature for 1.5 hours. The mixture is distilled under reduced pressure to remove methanol. The residue is adjusted to pH 4 with 10% HCl, and the precipitated crystals are collected by filtration, washed with water and then dried to give the title compound (1.0 g, 81%) as colorless needles, m.p. 225°-226° C.

後処理

  1. distillationThe mixture is distilled under reduced pressure
  2. customto remove methanol
  3. filtrationthe precipitated crystals are collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-830b5595f8d946fe892f1e19364044ce
出典データセット
uspto-grants-1986_12
特許番号
US04628057

反応ノート

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