Propylene Oxide → N-(2-hydroxypropyl)-N-methylmethanesulfonamide
反応式
[CH3:1][NH:2][S:3]([CH3:6])(=[O:5])=[O:4].[CH2:7]1[O:10][CH:8]1[CH3:9]>C(O)(C)(C)C>[CH3:1][N:2]([CH2:7][CH:8]([OH:10])[CH3:9])[S:3]([CH3:6])(=[O:5])=[O:4]参加物
4
実験手順
N-Methylmethanesulfonamide (21.8 grams; 0.2 mol), t-butylalcohol (50 ml) sodium hydride (0.5 grams; 50% in mineral oil), and propylene oxide (11.6 grams; 0.2 mol) were placed into a 3-necked glass reaction flask equipped with stopper, stirrer, thermometer, and reflux condenser. The mixture was heated at 50°-60° C. for three hours, cooled, and concentrated on a rotoevaporator. The concentrate was neutralized with concentrated hydrochloric acid (1 ml) and distilled under reduced pressure. Fractions 4 and 5 (13.2 grams; boiling point (140°-142° C./1.5 mm Hg) analyzed for the described product as follows:
後処理
- customequipped with stopper, stirrer
- temperaturethermometer, and reflux condenser
- temperatureThe mixture was heated at 50°-60° C. for three hours
- temperaturecooled
- concentrationconcentrated on a rotoevaporator
- distillationdistilled under reduced pressure
- custompoint (140°-142° C./1.5 mm Hg)
出典と根拠
- ORDレコード
- ord-b86e829853b64c8db56ae09c08e5a56b
- 出典データセット
- uspto-grants-1986_12
- 特許番号
- US04629497
反応ノート
読み込み中…