alpha,alpha-Diphenyl-4-piperidineethanol → HCID 13754500、化合物

HRID 1249565ノート

反応式

HRID 1249565 の反応式
[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(O)[CH2:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>FC(F)(F)C(O)=O>[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:8][CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 13754497alpha,alpha-Diphenyl-4-piperidineethanol

生成物 1

HCID 13754500HCID 13754500、化合物収率 92%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

The title compound was prepared by dissolving 20 g of alpha,alpha-diphenyl-4-piperidineethanol in 40 mL of anhydrous trifluoroacetic acid and stirring for 15 minutes. The volatiles were removed under vacuum and the residue was partitioned between toluene and 2N sodium hydroxide solution. The organic layers were dried over sodium sulfate, evaporated, and the residue was crystallized from hexane to give 17.2 g (92%) of 4-(2,2-diphenylethenyl)piperidine, mp 98°-99° C. Anal. Calcd for C19H21N: C, 86.65; H, 8,.04; N, 5.32. Found: C, 86.35; H, 7.97; N, 5.26.

後処理

  1. customThe title compound was prepared
  2. customThe volatiles were removed under vacuum
  3. customthe residue was partitioned between toluene and 2N sodium hydroxide solution
  4. dry with materialThe organic layers were dried over sodium sulfate
  5. customevaporated
  6. customthe residue was crystallized from hexane

出典と根拠

ORDレコード
ord-f51470da66eb4c81ad5361f4ed5153f9
出典データセット
uspto-grants-1986_12
特許番号
US04632925

反応ノート

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