1,6-Dimethyl-2-methoxymethyl-3-benzyloxypyridin-4(1H)-one hydrochloride → 1,6-Dimethyl-2-methoxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride
反応式
[ClH:1].[CH3:2][N:3]1[C:8]([CH3:9])=[CH:7][C:6](=[O:10])[C:5]([O:11]CC2C=CC=CC=2)=[C:4]1[CH2:19][O:20][CH3:21]>CO.O.[Pd]>[ClH:1].[CH3:2][N:3]1[C:8]([CH3:9])=[CH:7][C:6](=[O:10])[C:5]([OH:11])=[C:4]1[CH2:19][O:20][CH3:21]参加物
5
実験手順
1,6-Dimethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1 H)-one hydrochloride (1.55 g, 5 mmol) was dissolved in methanol (40 ml)/water (10 ml) and hydrogenated for 4 hours in the presence of 5% Pd/C (0.3 g). Following filtration the filtrate was concentrated in vacuo and the crude material recrystallised from methanol/diethyl ether gave the pure title compound (0.95 g, 86.5%) as a white crystalline solid. m.p. 156-159° C.
後処理
- filtrationfiltration the filtrate
- concentrationwas concentrated in vacuo
- customthe crude material recrystallised from methanol/diethyl ether
出典と根拠
- ORDレコード
- ord-3e2ed233ebb24e9faa2c019d315c7834
- 出典データセット
- uspto-grants-2002_01
- 特許番号
- US06335353B1
反応ノート
読み込み中…