Sodium Hydroxide → HCID 18329461、化合物
反応式
[CH:1]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:5]=1[C:12]1[O:13]CC(C)(C)N=1)([CH3:3])[CH3:2].[OH-:19].[Na+]>S(=O)(=O)(O)O>[CH:1]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:5]=1[C:12]([OH:13])=[O:19])([CH3:2])[CH3:3]参加物
4
実験手順
A solution of 2-(2-isopropyl-3-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole (6.18 g, 25 mmol) in 35% solution of sulfuric acid (40 mL) was stirred at reflux for 48 hours. Upon cooling, solid sodium hydroxide (18.15 g) was slowly added. The reaction mixture was extracted with diethyl ether, and the combined organic extracts were extracted with sodium bicarbonate solution. The bicarbonate extracts were then acidified with 3N hydrochloric acid, filtered and dried to give 2-isopropyl-3-methoxybenzoic acid as a white crystalline solid (1.73 g, 35.7%).
後処理
- temperatureat reflux for 48 hours
- temperatureUpon cooling
- extractionThe reaction mixture was extracted with diethyl ether
- extractionthe combined organic extracts were extracted with sodium bicarbonate solution
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-3ad4948b116840b2937f37c82abe7cd7
- 出典データセット
- uspto-grants-2002_01
- 特許番号
- US06335459B1
反応ノート
読み込み中…