Trifluoroacetic acid → HCID 15516970、化合物
反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:14]2[N:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[N:15]1[CH:16]=[CH:17][CH:18]=[N:19][C:14]=1[C:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=1参加物
4
実験手順
500 mg of the compound of step 2 of Example 25 was dissolved in 10 ml of methylene chloride, 3.5 ml of trifluoroacetic acid (hereinafter referred to as TFA) was added, then the resultant mixture was agitated at room temperature for 30 minutes. This was concentrated, then an aqueous solution of 10% sodium hydroxide was added and extraction was performed with chloroform. The organic layer was washed by saturated saline and was dried with anhydrous magnesium sulfate. This chloroform was concentrated to obtain the above-referenced compound in an amount of 260 mg (yield of 87%).
後処理
- additionwas added
- concentrationThis was concentrated
- additionan aqueous solution of 10% sodium hydroxide was added
- extractionextraction
- washThe organic layer was washed by saturated saline
- dry with materialwas dried with anhydrous magnesium sulfate
- concentrationThis chloroform was concentrated
- customto obtain the above-referenced compound in an amount of 260 mg (yield of 87%)
出典と根拠
- ORDレコード
- ord-113e3b6269224ed7a9aada12acbe05c7
- 出典データセット
- uspto-grants-2002_01
- 特許番号
- US06337397B1
反応ノート
読み込み中…