4-Chloro-2-toluidine → N-(4-Chloro-2-methyl-phenyl)-propane-1,3-diamine

HRID 1250874

反応式

HRID 1250874 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.Br.Br[CH2:12][CH2:13][CH2:14][NH2:15].[OH-].[Na+]>O>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:12][CH2:13][CH2:14][NH2:15])=[C:4]([CH3:9])[CH:3]=1

参加物

5

反応物 3

HCID 72514-Chloro-2-toluidineHCID 14798Sodium HydroxideHCID 787013-Bromopropylamine hydrobromide

生成物 1

HCID 18324816N-(4-Chloro-2-methyl-phenyl)-propane-1,3-diamine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-chloro-2-methylaniline (8 g) and 3-bromopropylamine hydrobromide (5 g) was heated at 100° C. for fifteen minutes. After cooling to room temperature, the resulting crystalline solid was dissolved in water (50 mL) and one equivalent of sodium hydroxide was added. This solution was then washed with ethyl ether and basified with excess sodium hydroxide. It was then extracted with dichloromethane, the combined extracts were dried over anhydrous potassium carbonate and evaporated to dryness.

後処理

  1. temperatureAfter cooling to room temperature
  2. washThis solution was then washed with ethyl ether and basified with excess sodium hydroxide
  3. extractionIt was then extracted with dichloromethane
  4. dry with materialthe combined extracts were dried over anhydrous potassium carbonate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-d50cdada08774a14b9f3f62287fcc4b9
出典データセット
uspto-grants-2002_01
特許番号
US06340687B1

関連ノート

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