Methyl iodide → 4-(4-Hydroxyphenyl)butanoic acid methyl ester

HRID 1250924

反応式

HRID 1250924 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1.[C:14](=O)(O)[O-].[Na+].IC>CN(C=O)C.O>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 2799834-(4-Hydroxyphenyl)butanoic acidHCID 516892Sodium Bicarbonate

生成物 1

HCID 1409044-(4-Hydroxyphenyl)butanoic acid methyl ester収率 74.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 0.69 g of 4-(4-hydroxyphenyl)butyric acid in 10 mL of DMF was added 0.956 g of sodium bicarbonate followed by 0.36 mL of iodomethane and the resulting mixture was stirred at room temperature for 5 h. The reaction was then diluted with water, extracted with ether, dried over MgSO4, filtered and concentrated in vacuo to provide 0.553 g of methyl 4(4-hydroxyphenyl)butyrate.

後処理

  1. extractionextracted with ether
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1acd6fb8e75e4f6cb52752d279aee71c
出典データセット
uspto-grants-2002_01
特許番号
US06340691B1

関連ノート

読み込み中…