Acetone Cyanohydrin → HCID 18323946、化合物

HRID 1251370ノート

反応式

HRID 1251370 の反応式
[O-]S([O-])(=O)=O.[Mg+2].[CH3:7][C:8]([N:10](C)C)=O.[OH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[S:20]1[CH2:25][CH2:24]C(=O)[CH2:22][CH2:21]1.CC(C)(O)C#N>>[OH:13][CH:14]1[CH2:19][CH2:18][N:17]([C:7]2([C:8]#[N:10])[CH2:24][CH2:25][S:20][CH2:21][CH2:22]2)[CH2:16][CH2:15]1

参加物

6

反応物 5

HCID 6406Acetone CyanohydrinHCID 24083Sulfuric acid magnesium salt (1:1)HCID 31374DimethylacetamideHCID 66173Tetrahydrothiopyran-4-oneHCID 79341Piperidin-4-ol

生成物 1

HCID 18323946HCID 18323946、化合物

実験手順

It is prepared from MgSO4 (7.2 g, 60 mmoles), DMA (2.62 g, 30 mmoles), 4-hydroxy-piperidine (3.03 g, 20 mmoles), tetrahydro-4H-thiopyran-4-one (2.32 g, 20 mmoles) and acetone cyanhydrin (1.7 g, 20 mmoles). After treatment of the reaction, a white solid is obtained (4.7 g) which is crystallized from anhydrous ether. In this way, white crystals are obtained (3.6 g, 79%). M.p.=79-81° C.

後処理

  1. customAfter treatment of the reaction
  2. customa white solid is obtained (4.7 g) which
  3. customis crystallized from anhydrous ether
  4. customIn this way, white crystals are obtained (3.6 g, 79%)

出典と根拠

ORDレコード
ord-eacb37ce01b34d108084f991eea0e370
出典データセット
uspto-grants-2002_01
特許番号
US06342511B1

反応ノート

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