2-Chloro-4,6-dimethylpyrimidine → N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine

HRID 1251496

反応式

HRID 1251496 の反応式
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([CH3:9])=[CH:4][N:3]=1.Cl[C:11]1[N:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[N:12]=1.[H-].[Na+]>CN(C=O)C>[Br:8][C:7]1[C:2]([NH:1][C:11]2[N:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[N:12]=2)=[N:3][CH:4]=[C:5]([CH3:9])[CH:6]=1

参加物

5

反応物 3

HCID 205502-Chloro-4,6-dimethylpyrimidineHCID 24758Sodium hydrideHCID 5193802-Amino-3-bromo-5-methylpyridine

生成物 1

HCID 18323693N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Part A: A 1.0 gram (5.35 mmol) portion of commercially available 2-amino-3-bromo-5-methylpyridine was coupled to 2-chloro-4,6-dimethylpyrimidine (Example 1; part A) using NaH (1.2 eq) in DMF to give N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine. C12H13N4Br MS 293 (M+H)+.

出典と根拠

ORDレコード
ord-d0d7ad7d02b24d16b962d4069d8984af
出典データセット
uspto-grants-2002_01
特許番号
US06342503B1

関連ノート

読み込み中…