Imidazole → 2-(Imidazol-1-yl)-1-(thiazol-2-yl)-ethanone
反応式
Br[CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][N:9]=1)=[O:4].[NH:10]1[CH:14]=[CH:13][N:12]=[CH:11]1>C(#N)C>[N:10]1([CH2:2][C:3]([C:5]2[S:6][CH:7]=[CH:8][N:9]=2)=[O:4])[CH:14]=[CH:13][N:12]=[CH:11]1参加物
4
実験手順
A mixture of 2-bromo-1-(thiazol-2-yl)ethanone (2.5 g; 12 mmol), acetonitrile (70 ml) and imidazole (1.65 g; 24 mmol) was stirred at ambient temperature for 1 hour. The mixture was evaporated to dryness and the residue partitioned between dichloromethane and water. The organic phase was separated, washed with saturated brine and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%).
後処理
- customThe mixture was evaporated to dryness
- customthe residue partitioned between dichloromethane and water
- customThe organic phase was separated
- washwashed with saturated brine
- customevaporated
出典と根拠
- ORDレコード
- ord-ae0976080057424194ef55c1a6f50ff3
- 出典データセット
- uspto-grants-2002_01
- 特許番号
- US06342765B1
反応ノート
読み込み中…