Sodium Hydroxide → 5-[1-(4-Fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid

HRID 1251902ノート

反応式

HRID 1251902 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)=[C:21]([CH:26]=2)[C:22]([O:24]C)=[O:23])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[C:11]2[CH3:15])=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=3)=[C:21]([CH:26]=2)[C:22]([OH:24])=[O:23])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[C:11]2[CH3:15])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 18324372Methyl 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoate

生成物 1

HCID 183243915-[1-(4-Fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid収率 45.2%

実験手順

Methyl 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoate (4.2 g, ˜8.8 mmol) was hydrolysed with aqueous sodium hydroxide solution under the usual conditions to give 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoic acid (1.84 g, ˜45% ) as a colourless gum.

出典と根拠

ORDレコード
ord-d61e547e760746fdb39dd245629a423c
出典データセット
uspto-grants-2002_01
特許番号
US06342765B1

反応ノート

読み込み中…