Dimethylformamide → 2-Propionylamino-4-chloromethylthiazole

HRID 1252050ノート

反応式

HRID 1252050 の反応式
Cl.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([CH2:8][Cl:9])[N:7]=1.CN(C)C=O.[C:15](Cl)(=[O:18])[CH2:16][CH3:17]>N1C=CC=CC=1>[C:15]([NH:2][C:3]1[S:4][CH:5]=[C:6]([CH2:8][Cl:9])[N:7]=1)(=[O:18])[CH2:16][CH3:17]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 62324Propionyl chlorideHCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)

生成物 1

HCID 103980162-Propionylamino-4-chloromethylthiazole収率 50.9%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a mixture of 2-amino-4-chloromethylthiazole hydrochloride (50 g), anhydrous N,N-dimethylformamide (250 ml) and anhydrous pyridine (50 ml) was added dropwise propionyl chloride (30 g) keeping the temperature below 3° C. with stirring and the mixture was stirred for 20 minutes at the same temperature. The reaction mixture was poured into ice water (1500 ml) and stirred. The crystal was collected by filtration and washed with water to give 2-propionylamino-4-chloromethylthiazole (28.15 g).

後処理

  1. customthe temperature below 3° C.
  2. stirringthe mixture was stirred for 20 minutes at the same temperature
  3. stirringstirred
  4. filtrationThe crystal was collected by filtration
  5. washwashed with water

出典と根拠

ORDレコード
ord-8e8a672ea0f1401db3ffc3191c2a785e
出典データセット
uspto-grants-1988_05
特許番号
US04742057

反応ノート

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