Sodium Hydroxide → 4-[4-(3-Indolyl)piperidinomethyl]-2-glycoloylaminothiazole

HRID 1252079ノート

反応式

HRID 1252079 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[N:18]=[C:19]([NH:22][C:23](=[O:29])[CH2:24][O:25]C(=O)C)[S:20][CH:21]=3)[CH2:12][CH2:11]2)=[CH:2]1.[OH-].[Na+]>C(O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]3[N:18]=[C:19]([NH:22][C:23](=[O:29])[CH2:24][OH:25])[S:20][CH:21]=3)[CH2:14][CH2:15]2)=[CH:2]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 141297994-[4-(3-Indolyl)piperidinomethyl]-2-(2-acetoxyacetylamino)thiazole

生成物 1

HCID 141298054-[4-(3-Indolyl)piperidinomethyl]-2-glycoloylaminothiazole収率 34.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 4-[4-(3-indolyl)piperidinomethyl]-2-(2-acetoxyacetylamino)thiazole (0.9 g) in ethanol (20 ml) was added 1N aqueous solution of sodium hydroxide (3 ml). After one hour of stirring, the reaction mixture was concentrated and the resulting precipitate was collected by filtration and recrystallized from a mixture of water and ethanol to give 4-[4-(3-indolyl)piperidinomethyl]-2-glycoloylaminothiazole (0.28 g).

後処理

  1. concentrationthe reaction mixture was concentrated
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from a mixture of water and ethanol

出典と根拠

ORDレコード
ord-f8b177ca19dd43c4bacff1b125b8ecc9
出典データセット
uspto-grants-1988_05
特許番号
US04742057

反応ノート

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