Ethanol → Sbb043676
反応式
C(O)C.[NH2:4][C:5]1[S:6][C:7]([SH:10])=[N:8][N:9]=1.[OH-].[Na+].Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>O>[NH2:4][C:5]1[S:6][C:7]([S:10][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[N:8][N:9]=1参加物
6
実験手順
To 190 ml of ethanol and 240 ml of water, 81.5 g of 2-amino-5-mercapto-1,3,4-thiadiazole and 26.9 g of sodium hydroxide were added. To this mixture 99.0 g of 1-bromohexane was added and the resulting mixture was stirred at 60°-70° C. for 2 hours. After cooling, water was added to the mixture and the mixture was filtered. The residue was washed with water, dried under reduced pressure, and recrystallized from an ethanol/hexane mixture. Thus 100.5 g of 2-amino-5-hexylthio-1,3,4-thiadiazole was obtained. m.p. 113°-115° C. Yield 77%.
後処理
- temperatureAfter cooling
- filtrationthe mixture was filtered
- washThe residue was washed with water
- customdried under reduced pressure
- customrecrystallized from an ethanol/hexane mixture
出典と根拠
- ORDレコード
- ord-5c2db0debd1f48c0a317cc74015b94a9
- 出典データセット
- uspto-grants-1988_05
- 特許番号
- US04742063
反応ノート
読み込み中…