2-(4-Benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine → 6-Ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

HRID 1252283ノート

反応式

HRID 1252283 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[C:23](=[O:24])[N:22]([CH2:25][CH3:26])[CH2:21][CH2:20][C:18]=3[N:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:25]([N:22]1[CH2:21][CH2:20][C:18]2[N:19]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:15]=[CH:16][C:17]=2[C:23]1=[O:24])[CH3:26]

参加物

5

反応物 2

HCID 137841212-(4-Benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 137841226-Ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine収率 96.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

In 20 ml of ethanol was dissolved 0.70 g of 2-(4-benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine. Thereto was added 10% Pd-C, and the resulting mixture was stirred at 60° C. for 4 hours in a hydrogen atmosphere. After having been allowed to cool, the mixture was filtered to remove the catalyst and the filtrate was concentrated to obtain 0.50 g of 6-ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as a crystal with an yield of 96%. The crystal was purified by immersion using ethyl acetate.

後処理

  1. temperatureto cool
  2. filtrationthe mixture was filtered
  3. customto remove the catalyst
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-80d50aaf71c8454aa406bba0069876ea
出典データセット
uspto-grants-1988_05
特許番号
US04742165

反応ノート

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