Water → HCID 20139720、化合物

HRID 1252329ノート

反応式

HRID 1252329 の反応式
[OH-].[Na+].[CH2:3]([C:6]1[CH:7]=[C:8]2[C:14](=[O:15])[N:13]([C:16]([CH:21]([CH3:23])[CH3:22])([CH3:20])[C:17]([NH2:19])=[O:18])[C:12](=O)[C:9]2=[N:10][CH:11]=1)[CH2:4][CH3:5].O>C1(C)C=CC=CC=1>[CH:21]([C:16]1([CH3:20])[N:13]2[C:14](=[O:15])[C:8]3[C:9](=[N:10][CH:11]=[C:6]([CH2:3][CH2:4][CH3:5])[CH:7]=3)[C:12]2=[N:19][C:17]1=[O:18])([CH3:23])[CH3:22]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 20139714alpha-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-alpha-isopropyl-alpha-methyl-acetamide

生成物 1

HCID 20139720HCID 20139720、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

With the simultaneous addition of 0.5 g of powdered sodium hydroxide, a solution of α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide (m.p.: 82° C.) in 100 ml of toluene is heated under reflux for 2 hours in a water separator. After the reaction solution has cooled, it is filtered through silica gel and the filtrate is washed with ethyl acetate and then concentrated by evaporation. The residue is recrystallised from ethyl acetate/petroleum ether, affording 13.1 g of the title compound which melts at 116° C.

後処理

  1. temperatureAfter the reaction solution has cooled
  2. filtrationit is filtered through silica gel
  3. washthe filtrate is washed with ethyl acetate
  4. concentrationconcentrated by evaporation
  5. customThe residue is recrystallised from ethyl acetate/petroleum ether

出典と根拠

ORDレコード
ord-83d5c0794eba442c8f9aeb6bdb712243
出典データセット
uspto-grants-1988_05
特許番号
US04743296

反応ノート

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