Sulfuric Acid → HCID 13090699、化合物

HRID 1252653ノート

反応式

HRID 1252653 の反応式
[CH3:1][C:2](=[CH2:4])[CH3:3].[Cl:5][C:6]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][C:7]=1[O:8][C:9]1[CH:10]=[C:11]([C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=1)[CH2:12][OH:13].S(=O)(=O)(O)O>ClCCCl>[C:2]([O:13][CH2:12][C:11]1[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=[C:9]([O:8][C:7]2[CH:20]=[CH:21][C:22]([C:24]([F:25])([F:26])[F:27])=[CH:23][C:6]=2[Cl:5])[CH:10]=1)([CH3:3])([CH3:1])[CH3:4]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 13050461HCID 13050461、化合物

生成物 1

HCID 13090699HCID 13090699、化合物収率 89%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

Isobutylene gas was passed into a solution of 17.4 parts by weight of 3-(2'-chloro-4'-trifluoromethylphenoxy)-6-nitrobenzyl alcohol in 100 parts by volume of 1,2-dichloroethane and 0.5 parts by weight of sulfuric acid at 40° C. for two hours. The reaction mixture was then washed with dilute aqueous sodium bicarbonate solution and twice with water, and the organic phase was dried with magnesium sulfate, filtered and concentrated. 18 parts by weight (89% of theory) of 3-(2'-chloro-4'-trifluoromethylphenoxy)-6-nitrobenzyl tert.-butyl ether (compound No. 16) of melting point 75°-78° C. were obtained.

後処理

  1. washThe reaction mixture was then washed with dilute aqueous sodium bicarbonate solution and twice with water
  2. dry with materialthe organic phase was dried with magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-7c9708faba114c70802d766b663561d9
出典データセット
uspto-grants-1988_05
特許番号
US04744812

反応ノート

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