1-[3-Mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-proline → HCID 53645761、化合物
反応式
[SH:1][CH2:2][CH:3]([CH2:14][C:15]([O:17]C)=[O:16])[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5].[H][H]>CO.[OH-].[Na+]>[C:15]([CH2:14][CH:3]([CH2:2][SH:1])[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5])([OH:17])=[O:16]参加物
5
実験手順
To a solution of the product from Example 62, Step (d) (3.0 g) in methanol (60 ml), 1N sodium hydroxide (60 ml) is added. After 4 hours, the solution is applied to a column of Dowex 50 ion exchange resin in the hydrogen cycle, and the desired material is eluted with water to yield 2.3 g of the named product, Rf =0.2 (silica gel-benzene:acetic acid, 75:25).
後処理
- washthe desired material is eluted with water
出典と根拠
- ORDレコード
- ord-1376bf65a11241a09961188ac94a9f88
- 出典データセット
- uspto-grants-1988_05
- 特許番号
- US04745124
反応ノート
読み込み中…