Dimethylformamide → HCID 13055728、化合物

HRID 1253003ノート

反応式

HRID 1253003 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2.C(=O)([O-])[O-].[K+].[K+].[Br:19][CH2:20][CH2:21][CH2:22]Br.CN(C)C=O>O>[Br:19][CH2:20][CH2:21][CH2:22][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 27740406-Hydroxy-3,4-dihydro-2(1H)-quinolinone

生成物 1

HCID 13055728HCID 13055728、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 12.6 g (0.076 mol) of 6-hydroxy-1,2,3,4-tetrahydro-2-quinolinone, 15.8 g (0.115 mol) of potassium carbonate (anhydrous and powdered), 46.5 g (0.23 mol) of 1,3-dibromopropane and 40 ml of N,N-dimethylformamide is stirred at room temperature for 20 hours. 200 ml of water and 100 ml of petroleum ether are added and, after stirring for 1 hour, the precipitate which has formed is filtered off with suction, washed with petroleum ether and dried.

後処理

  1. stirringafter stirring for 1 hour
  2. customthe precipitate which has formed
  3. filtrationis filtered off with suction
  4. washwashed with petroleum ether
  5. customdried

出典と根拠

ORDレコード
ord-aeb31252e9404d748858c580644f4b19
出典データセット
uspto-grants-1988_05
特許番号
US04746661

反応ノート

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