Thionyl Chloride → 1-benzyl-2-(chloromethyl)-1H-imidazole

HRID 1253030

反応式

HRID 1253030 の反応式
[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH2:13]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>>[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH2:13][Cl:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 311778(1-benzyl-1H-imidazol-2-yl)methanol

生成物 1

HCID 7367921-benzyl-2-(chloromethyl)-1H-imidazole収率 93.5%

実験手順

A mixture of 10 gm (45 mmole) of N-benzyl-2-hydroxymethylimidazole and 11 gm (92 mmole) of thionyl chloride was stirred at room temperature for 30 minutes before it was heated to reflux for 30 minutes. The excess thionyl chloride was removed under reduced pressure. The resultant residue (10 gm crude) was crystallized from ethanol/ether to obtain 8.7 gm of N-benzyl-2-chloromethylimidazole, m.p. 180°-182° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 30 minutes
  3. customThe excess thionyl chloride was removed under reduced pressure
  4. customThe resultant residue (10 gm crude) was crystallized from ethanol/ether

出典と根拠

ORDレコード
ord-39fad1f746cd4c8a807fe30658bab454
出典データセット
uspto-grants-1988_05
特許番号
US04746669

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