Ammonium Chloride → 5-(4-[2-Propylguanidino]pyrimid-2-yl)valeramidine hydrochloride

HRID 1253165

反応式

HRID 1253165 の反応式
[CH2:1]([N:4]=[C:5]([NH2:21])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH2:13][CH2:14][CH2:15][CH2:16][C:17](=[NH:20])OC)[N:8]=1)[CH2:2][CH3:3].[Cl-:22].[NH4+:23]>CO>[ClH:22].[CH2:1]([N:4]=[C:5]([NH2:21])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]([NH2:23])=[NH:20])[N:8]=1)[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 25517Ammonium ChlorideHCID 20137162Methyl 5-(4-[2-propylguanidino]pyrimid-2-yl)valerimidate

生成物 1

HCID 201371495-(4-[2-Propylguanidino]pyrimid-2-yl)valeramidine hydrochloride収率 93.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of methyl 5-(4-[2-propylguanidino]pyrimid-2-yl)valerimidate (0.4 g.) and ammonium chloride (0.076 g.) in MeOH (20 ml.) was stirred at ambient temperature for 1 hour and the solvent evaporated in vacuo to give 5-(4-[2-propylguanidino]pyrimid-2-yl)valeramidine hydrochloride (0.4 g.) as an oil which was used without further purification.

後処理

  1. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-9f68561694d34a0d9c0e9e77265079fc
出典データセット
uspto-grants-1988_05
特許番号
US04748165

関連ノート

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