alpha-Amino-7-ethyl-1H-indole-3-acetic Acid Ethyl Ester → HCID 14010222、化合物
反応式
C([O:3][C:4](=O)[CH:5]([NH2:17])[C:6]1[C:14]2[C:9](=[C:10]([CH2:15][CH3:16])[CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1)C.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[NH2:17][CH:5]([C:6]1[C:14]2[C:9](=[C:10]([CH2:15][CH3:16])[CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1)[CH2:4][OH:3]参加物
4
実験手順
α-Amino-7-ethyl-1H-indole-3-acetic acid ethyl ester 6 (4.9 g, 0.02 mol) in THF (50 mL) was added to LiAlH4 (2.3 g, 0.06 mol) in THF (25 mL) and the mixture was refluxed for 2 hours to give β-amino-7-ethyl-1H-indole-3-ethanol 7 (3.5 g, 85.7%). A sample recrystallized from ethyl acetate-hexane had m.p. 84°-86° C.
後処理
- temperaturethe mixture was refluxed for 2 hours
出典と根拠
- ORDレコード
- ord-68064e06e3124850a49363a4bef0eac3
- 出典データセット
- uspto-grants-1988_05
- 特許番号
- US04748252
反応ノート
読み込み中…