Hydrochloric Acid → 2-(4-Acetyl-2-n-propyl-3-hydroxyphenoxy)-2-(4-methoxyphenyl) acetic acid
反応式
[C:1]([C:4]1[CH:24]=[CH:23][C:7]([O:8][CH:9]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[C:10]([O:12]CC)=[O:11])=[C:6]([CH2:25][CH2:26][CH3:27])[C:5]=1[OH:28])(=[O:3])[CH3:2].[OH-].[Na+].Cl>>[C:1]([C:4]1[CH:24]=[CH:23][C:7]([O:8][CH:9]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[C:10]([OH:12])=[O:11])=[C:6]([CH2:25][CH2:26][CH3:27])[C:5]=1[OH:28])(=[O:3])[CH3:2]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 4.5 g of Ethyl 2-(4-acetyl-2-n-propyl-3-hydroxyphenoxy)-2-(4-methoxyphenyl)acetate and 150 ml of 1 Normal sodium hydroxide was stirred at 80° C. for 2 hours. The reaction mixture was then cooled, acidified with 1 Normal hydrochloric acid, extracted with ethyl acetate, treated with charcoal, filtered and concentrated to dryness to give an oily residue which was crystallized from EtOAc/hexane, yielding 0.9 g of product, melting point 154°-156° C.