Acetic acid, azido-, ethyl ester → Ethyl (2Z,4E)-2-azido-5-(4-methylphenyl)penta-2,4-dienoate

HRID 12535

反応式

HRID 12535 の反応式
CC[O-].[Na+].[CH3:5][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[CH:14]=O)=[CH:8][CH:7]=1.[N:16]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[N+:17]=[N-:18]>C(O)C>[N:16](/[C:19](=[CH:14]\[CH:13]=[CH:12]\[C:9]1[CH:8]=[CH:7][C:6]([CH3:5])=[CH:11][CH:10]=1)/[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[N+:17]=[N-:18]

参加物

5

反応物 3

HCID 69480Acetic acid, azido-, ethyl esterHCID 2723922Sodium ethoxideHCID 5371802p-Methylcinnamaldehyde2 回

生成物 1

HCID 12378027Ethyl (2Z,4E)-2-azido-5-(4-methylphenyl)penta-2,4-dienoate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Following General Procedure I, a 1.38 M solution of NaOEt in ethanol (30 ml), (E)-3-(4-methylphenyl)acrylaldehyde (Compound 43, 1.1 g, 7.5 mmol) and ethyl azidoacetate (12 ml, 37.5 mmol) in EtOH (20 ml) were reacted to produce the title compound as a solid.

出典と根拠

ORDレコード
ord-b4766f87ad664e35965873e1b072eb02
出典データセット
uspto-grants-2010_06
特許番号
US07728014B2

関連ノート

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