Hydrochloric Acid → HCID 67207576、化合物
反応式
[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][CH:3]1[C:12]([O:14]CC)=[O:13].Cl>[OH-].[Na+]>[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][CH:3]1[C:12]([OH:14])=[O:13]参加物
4
実験手順
Ethyl 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylate (1.8 g, 8.2 mmol) was dissolved in 4% aqueous sodium hydroxide (80 ml). The reaction mixture was heated to reflux for 4 hours, cooled to room temperature, and then adjusted to pH=4 with 2N hydrochloric acid. The reaction mixture was filtered to give 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylic acid.
後処理
- temperatureThe reaction mixture was heated
- temperatureto reflux for 4 hours
- filtrationThe reaction mixture was filtered
出典と根拠
- ORDレコード
- ord-6208b97a707f4d3e9b183dca491b5fe4
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08455477B2
反応ノート
読み込み中…