Trifluoroacetic acid → 8-(Pyridin-3-yl)-2,8-diazaspiro[4.5]decane
反応式
C(O)(C(F)(F)F)=O.[N:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N:14]2[CH2:30][CH2:29][C:17]3([CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)[CH2:16][CH2:15]2)[CH:9]=1>C(Cl)Cl>[N:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N:14]2[CH2:30][CH2:29][C:17]3([CH2:21][NH:20][CH2:19][CH2:18]3)[CH2:16][CH2:15]2)[CH:9]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
TFA (2 ml) was added to a solution of tert-butyl 8-(pyridine-3-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (1.14 mmol, 1.0 eq.) in methylene chloride (6 ml) at 0° C. and the reaction mixture was stirred at 25° C. for 2 h. When the reaction was complete, the solvent was concentrated in vacuo in order to obtain the desired amine (AMN-24).
後処理
- concentrationthe solvent was concentrated in vacuo in order
出典と根拠
- ORDレコード
- ord-851fae3a659e4785922cb37db6f186b2
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08455475B2
反応ノート
読み込み中…