Trifluoroacetic acid → 2,2,2-Trifluoro-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone

HRID 1253750ノート

反応式

HRID 1253750 の反応式
C(O)(C(F)(F)F)=O.[F:8][C:9]([F:30])([F:29])[C:10]([N:12]1[CH2:28][CH2:27][C:15]2([CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:14][CH2:13]1)=[O:11]>>[F:30][C:9]([F:8])([F:29])[C:10]([N:12]1[CH2:28][CH2:27][C:15]2([CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13]1)=[O:11]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 59505224Tert-butyl 8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carboxylate

生成物 1

HCID 595052392,2,2-Trifluoro-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone

実験手順

TFA (1 ml) was added to a stirred solution of tert-butyl 8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (840 mg, 2.5 mmol) in MC (4 ml) and the mixture was stirred at RT for 12 h. The reaction mixture was then concentrated under reduced pressure and azeotroped with MC (2×10 ml). The crude product was dried and used for the next step without further purification.

後処理

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customazeotroped with MC (2×10 ml)
  3. dry with materialThe crude product was dried
  4. customused for the next step without further purification

出典と根拠

ORDレコード
ord-6793d3e5bd36422d9e469b9ee9667c7c
出典データセット
uspto-grants-2013_06
特許番号
US08455475B2

反応ノート

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