N-(5-(7-Bromobenzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide → N-(5-(Benzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide

HRID 1255123

反応式

HRID 1255123 の反応式
Br[C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([C:11]2[S:15][C:14]([NH:16][C:17](=[O:26])[C:18]3[C:23]([F:24])=[CH:22][CH:21]=[CH:20][C:19]=3[F:25])=[N:13][C:12]=2[CH3:27])[CH:3]=1>CCO.[Pd]>[O:8]1[C:7]2[CH:2]=[CH:3][C:4]([C:11]3[S:15][C:14]([NH:16][C:17](=[O:26])[C:18]4[C:23]([F:24])=[CH:22][CH:21]=[CH:20][C:19]=4[F:25])=[N:13][C:12]=3[CH3:27])=[CH:5][C:6]=2[O:10][CH2:9]1

参加物

4

反応物 1

HCID 24765405N-(5-(7-Bromobenzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide

生成物 1

HCID 24765406N-(5-(Benzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide収率 89.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of Compound 56 (50 mg) and 10% Pd/C (10 mg) in EtOH (2.0 mL) was stirred under an atmosphere of hydrogen gas overnight. The mixture was filtered through a short plug of celite. The filtrate was concentrated under reduced pressure to give Compound 57 (37 mg).

後処理

  1. filtrationThe mixture was filtered through a short plug of celite
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-1633d1f55bc040fe830af7ca214998b6
出典データセット
uspto-grants-2013_06
特許番号
US08455658B2

関連ノート

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