Trifluoroacetic acid → 2,6-difluoro-N-(4-(prop-1-en-2-yl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide

HRID 1255131ノート

反応式

HRID 1255131 の反応式
[F:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)=[C:10]([C:12](O)([CH3:14])[CH3:13])[N:11]=1)=[O:5].C(O)(C(F)(F)F)=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:24])[F:25])[CH:17]=2)=[C:10]([C:12]([CH3:14])=[CH2:13])[N:11]=1)=[O:5]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 247655782,6-Difluoro-N-(4-(2-hydroxypropan-2-yl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide

生成物 1

HCID 247655792,6-difluoro-N-(4-(prop-1-en-2-yl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide収率 95%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Into a solution of Compound 68 (22 mg, 0.05 mmol) in 5 mL of toluene was added dropwise of 0.2 mL of TFA. The mixture was heated to reflux for 30 minutes. After cooled down to room temperature, the reaction was concentrated. The residue was purified by column chromatography on silica gel (10-20% EtOAc in hexanes) to give Compound 68a (20 mg, 95%) as a white solid.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 30 minutes
  3. concentrationthe reaction was concentrated
  4. customThe residue was purified by column chromatography on silica gel (10-20% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-c80198d2b8ca4d768c80c2c0f98cf101
出典データセット
uspto-grants-2013_06
特許番号
US08455658B2

反応ノート

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