Dichloromethane → N-(2-Sulfanylethyl)pentanamide

HRID 1255371ノート

反応式

HRID 1255371 の反応式
Cl.[SH:2][CH2:3][CH2:4][NH2:5].C(=O)([O-])[O-].[K+].[K+].[C:12](Cl)(=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16].ClCCl>O>[SH:2][CH2:3][CH2:4][NH:5][C:12](=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16]

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 9082Cysteamine HydrochlorideHCID 11430Potassium CarbonateHCID 61186Valeryl chloride

生成物 1

HCID 22222175N-(2-Sulfanylethyl)pentanamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
40 °C

実験手順

Under a nitrogen atmosphere, 22.7 g of 2-mercaptoethylamine hydrochloride (0.2 mol) and 44.3 g of potassium carbonate (0.32 mol) were introduced at room temperature in solution in 130 ml of water. The solution was warmed to 40° C. and 12.0 g of valeryl chloride (0.1 mol) were added dropwise over the course of 15 minutes. The batch was stirred at 40° C. for 3 hours and then cooled to room temperature. 70 ml of dichloromethane were added and a phase separation was carried out. The organic phase was washed with 50 ml of 20% strength ammonium chloride solution, dried over sodium sulfate and freed of its solvent under reduced pressure.

後処理

  1. temperaturecooled to room temperature
  2. customa phase separation
  3. washThe organic phase was washed with 50 ml of 20% strength ammonium chloride solution
  4. dry with materialdried over sodium sulfate

出典と根拠

ORDレコード
ord-f51eeac01e55452eae8f120abb552573
出典データセット
uspto-grants-2013_06
特許番号
US08460445B2

反応ノート

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