Hydrazine hydrate (1:1) → N4-Phenylquinazoline-4,6-diamine

HRID 1255977

反応式

HRID 1255977 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][N:8]=[C:7]2[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([O-])=O.O.NN>C(O)C.O.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][N:8]=[C:7]2[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 53281896-Nitro-N-phenylquinazolin-4-amine

生成物 1

HCID 5328187N4-Phenylquinazoline-4,6-diamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 19096565Water ethanol溶媒

実験手順

A solution of a 6-nitro-4-(phenylamino)quinazoline substituted by a polyalkylene glycol, prepared as described hereinabove, in ethanol/water is reacted at reflux temperature with hydrazine hydrate and Raney® Nickel (Ra—Ni). The reaction mixture is filtered and evaporated, to give the corresponding 6-amino-4-(phenylamino)quinazoline substituted by a polyalkylene glycol moiety (terminating with a hydroxyl group).

後処理

  1. customprepared
  2. filtrationThe reaction mixture is filtered
  3. customevaporated

出典と根拠

ORDレコード
ord-1bcbd8072ef14c7a9ae4b6e886275640
出典データセット
uspto-grants-2013_06
特許番号
US08461166B2

関連ノート

読み込み中…