Dimethylformamide → 1,2-Difluoro-4-methoxy-5-nitrobenzene
反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([OH:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].CN(C=O)C.IC>O>[F:1][C:2]1[CH:3]=[C:4]([N+:10]([O-:12])=[O:11])[C:5]([O:9][CH3:13])=[CH:6][C:7]=1[F:8]参加物
6
実験手順
4,5-Difluoro-2-nitrophenol (INTERMEDIATE 51) (2.02 g, 11.54 mmol) and potassium carbonate (2.39 g, 17.3 mmol) were added into a 50 mL round-bottomed flask. DMF (10 mL) was added. Iodomethane (1.08 mL, 17.3 mmol) was added. The reaction mixture was stirred at RT overnight. The mixture was poured into water (60 mL) and stirred for 10 min. Filtration afforded the title product as a precipitate (1.9 g, 87% yield).
後処理
- stirringstirred for 10 min
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-e861ab369cf9464fbbbf7063492c228c
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461170B2
反応ノート
読み込み中…